Mental health studies

Mental health studies

Genetic Links to Anxiety and Depression (GLAD)

The study is set to explore risk factors in individuals who have experienced depression and/or anxiety, including those with a diagnosis of bipolar disorder, OCD, or related disorders, at any time of their life. It aims to better understand depression and anxiety in order to find and develop more effective treatment. The GLAD study is also part of the NIHR BioResource, which is a library of information about people’s health aiming to support research in both physical and mental health. The study involves an online questionnaire at www.gladstudy.org.uk and if eligible you will need to send a saliva DNA sample through the post using the freepost envelope provided by the GLAD study team.

Hearing Nasty Voices 

Study which is looking to understand why people can find their auditory hallucinations difficult to ignore or dismiss. Participants who experience voices that are critical and/or derogatory will complete a set of questionnaires online or on paper and receive £5 on completion.

ODDESSI

ODDESSI is a large-scale programme of research into crisis and continuing mental health care within the NHS.There are several questions that the research is examining: 

  1. Can we develop a way to offer Open Dialogue in the NHS that is acceptable to staff (including peers) and service-users? Does it fit in with how existing NHS services operate?
  2. Does offering Open Dialogue result in good clinical outcomes, and is it worth the money?
  3. What is the experience of service users, carers, and staff?

Transformation in Mental Healthcare: An Anthropological Study of Open Dialogue (OD) in the UK's National Health Service – APOD

The PhD project investigates Peer-Supported Open Dialogue as an approach to crisis care in the London borough of Haringey, characterised by economic inequality and ethnic/cultural diversity. It aims to explain how POD works in practice, the social dynamics of mental health teams and clients, and the experience of different roles (clinician, peer-worker, client, carer). Why and for whom the Open Dialogue approach works (or fails to), what are the relevant contextual and cultural factors. it will investigate the intersections of professional care networks and community social networks to learn what allows connection and recovery.

The ethnographic research is taking place alongside a UCL-led randomised controlled trial (ODDESSI) to establish whether on average people in crisis receiving Open Dialogue do better than treatment as usual.

OPAINT

This trial is a Randomised, double-blind, placebo controlled trial evaluating the effects of naloxone hydrochloride nasal spray on eating behaviours in bulimianervosa. Naloxone hydrochloride nasal spray is being developed by Opiant Pharmaceuticals (Santa Monica, USA), the Sponsor of the study, for treating eating behaviours in patients with bulimia nervosa. The aim of this study is to find out how well the nasal spray affects binging and eating behaviours including risk taking and control of risks in patient with bulimia nervosa.  The study will also see how dosing once or once or twice a day with the study medication or placebo over an 8-week period affects eating behaviours in patients with bulimia nervosa.The study will also look at the safety of the nasal spray in patients with bulimia nervosa.

BRiGhTMIND Study

The study is researching the effectiveness of two types of Transcranial Magnetic Stimulation treatments designed to help people who are experiencing depression for which traditional treatments like medication and talking therapies or counselling haven’t worked. This type of depression is called treatment resistant depression.

Flare

Clinical trial to investigate the early intervention of mild COVID-19 in healthcare workers with broad-spectrum antivirals. There is an urgent need for effective, early treatments for COVID-19, so this Phase IIA trial is evaluating two oral antivirals: favipiravir (used for influenza) and lopinavir/ritonavir (used for HIV).

ISARIC WHO Clinical Characterisation Protocol for Severe Emerging Infections UK (CCP-UK)

This study will provide rapid, coordinated clinical investigation of patients with confirmed COVID-19 infection. It will look at how the virus reproduces and is excreted by the body, how the body responds to infection and treatment over time and how the immune system responds

OPTIONS

This is a short survey to understand the attitudes and opinions of staff, working across NHS Sites in England, to the change in law regarding organ donation. The link to the survey and further information can be found below:

https://bit.ly/optionsstudy

Please note this closes on 31 December 2020.

If you would like further details on any of these, or a full list of studies BEH are currently supporting, please contact the R&D team;

R&D Dept.

Block 28

St. Ann’s Hospital

London

N15 3TH

Tel:  0208 702 5627

Email: beh-tr.research@nhs.net

Twitter: @BEHResearch