Dementia studies

Dementia Studies

SYMBAD

A trial on Mirtazapine and Carbamazepine for Agitation in Dementia. This trial's aim is to assess the safety, clinical and cost effectiveness of mirtazapine and carbamazepine in the treatment of agitation in dementia. The null hypothesis is that there is no difference in CMAI scores between patients treated with placebo and mirtazapine, and between patients treated with placebo and carbamazepine, at 12 weeks.

Liz Sampson

IDEAS

This study will develop a psychological intervention based on behavioural activation to prevent depressive symptoms arising or worsening in people with early-stage dementia. The secondary objective is to assess the feasibility and acceptability of the intervention via a feasibility Randomised Controlled Trial (RCT) to inform a future fully powered RCT of clinical effectiveness. The study is being run by University College London (UCL).

Janina Brede 

Ni & Amyloid

This study is investigating neuroinflammation and amyloid build-up in patients with Alzheimer’s disease, mild cognitive impairment and healthy volunteers, using PET and CT imaging.

Dr Melanie Dani

BDR-Donor Recruitment

The aim is to invite people diagnosed with a memory impairment (or dementia) to participate in monitoring of memory, thinking and behaviour, as well as donating brain tissue upon death. We also invite those who do not have a memory impairment to take part as normal tissue is essential for comparison. Volunteers will be required to be assessed every year.

Dr Melanie Dani

Late onset of Depression

This study aims to establish whether depression with onset above 55 years is associated with other motor, non-motor and imaging markers of prodromal PD. Although final proof of its predictive value for clinical PD will require further follow-up, the present study will provide important information on the abnormalities seen at the earliest stages of PD indicative of later diagnosis of PD.

Hiba Kazmi

4 Mountains Test Predictive study

This study aims therefore to assess the specificity of the 4MT as a diagnostic test for early AD by undertaking this test in patients with a variety of diseases causing dementia. In order to further understanding of the relationships between test performance, disease state and brain involvement, 4MT results will be compared with measurements of brain structure and function as obtained via MRI.

C-DEMQOL

 Quality of life in family carers of people with dementia. Aims of this study is to develop and test a new instrument (C-DEMQOL) to measure QOL in family carers of people with dementia in research and health and social care services to monitor quality of life in carers. 

CDEMOQOL- will enable evaluation of QOL across the range of caring situations, severity and complexity of dementia.

For further information on any of the dementia studies listed, or to enquire about joining our on-going research register: DemReg for people with memory problems, confusion and/or dementia, please contact:

Tom Freeth, Clinical Research Officer. Tel: 020 8702 3556; Email: tom.freeth@nhs.net